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2023 - January

Human intestinal epithelial cells can internalize luminal fungi via LC3-associated phagocytosis.

Cohen-Kedar, S. et al. (BioRxiv) doi:10.1101/2022.12.14.520372

Immunogenicity of non-canonical HLA-I tumor ligands identified through proteogenomics

Lozano-Rabella, M. et al. (BioRxiv) DOI: 10.1101/2022.11.07.514886

2022 - November

B cell depletion attenuates CD27 signaling of T helper cells in multiple sclerosis

Ulutekin, C. et al. (medRxiv) doi:10.1101/2022.10.17.22281079

Cystatin F (Cst7) drives sex-dependent changes in microglia in an amyloid-driven model of Alzheimer’s Disease

Daniels, M.J.D. et al. (BioRxiv) doi: 10.1101/2022.11.18.516922

Selected Nature Reviews Immunology Highlight

Enhanced STAT5a activation rewires exhausted CD8 T cells during chronic stimulation to acquire a hybrid durable effector like state

Beltra, J-C. et al. (BioRxiv) doi: 10.1101/2022.10.03.509766

Selected Nature Reviews Immunology Highlight

2022 - October

Release of the pre-assembled naRNA-LL37 composite DAMP re-defines neutrophil extracellular traps (NETs) as intentional DAMP webs

Bork, F. et al. (BioRxiv) doi: 10.1101/2022.07.26.499571

Single-cell transcriptomics of resected human traumatic brain injury tissues reveals acute activation of endogenous retroviruses in oligodendrocytes

Garza, R. et al. (BioRxiv) doi: 10.1101/2022.09.07.506982

Eradication of tumors with pre-existing antigenic heterogeneity by vaccine-mediated co-engagement of CAR T and endogenous T-cells

Ma, Y. et al. (BioRxiv) doi: 10.1101/2022.10.05.511036

Selected Nature Reviews Immunology Highlight

2022 - September

Long-term retention of antigens in germinal centres is controlled by the spatial organisation of the follicular dendritic cell network

Martinez-Riano, A. et al. (BioRxiv) doi: 10.1101/2022.09.06.506650

Selected Nature Reviews Immunology Highlight

2022 - June

A unique epigenomic landscape defines CD8+ tissue-resident memory T cells 

Buquicchio, F. et al. (BioRxiv) doi: 10.1101/2022.05.04.490680

Selected Nature Reviews Immunology Highlight

GATA4 regionalizes intestinal metabolism and barrier function to prevent immunopathology 

Earley, Z. et al. (BioRxiv) doi: 10.1101/2021.10.28.466194

Terminal differentiation and persistence of effector regulatory T cells essential for the prevention of intestinal inflammation 

Dikiy, S. et al. (BioRxiv) doi: 10.1101/2022.05.16.492030

2022 - May

Integrated protein and transcriptome high-throughput spatial profiling

Ben-Chetrit N. et al. (BioRxiv) doi: 10.1101/2022.03.15.484516

Induction of a CD8 T cell intrinsic DNA damage and repair response isassociated with clinical response to PD-1 blockade in uterine cancer

Muroyama, Y. et al. (BioRxiv) doi: 10.1101/2022.04.16.488552

Unaltered T cell responses to common antigens in individuals with Parkinson’s disease

Williams, G.P. et al. (BioRxiv) doi: 10.1101/2022.04.05.487195

Sex differences in NK cells mediated by the X-linked epigenetic regulator UTX

Cheng, M. et al. (BioRxiv) doi: 10.1101/2022.04.21.489076

Selected Nature Reviews Immunology Highlight

Brain resident memory T cells rapidly expand and initiate neuroinflammatory responses following CNS injury and viral infection

Ayasoufi, K. et al. (BioRxiv) doi: 10.1101/2022.04.08.487707

Distinct gene expression by expanded clones of quiescent memory CD4+ T cells harboring intact latent HIV-1 proviruses 

Weymar, G.H.J. et al. (BioRxiv) doi: 10.1101/2022.03.02.482683

2022 - April

Immune checkpoint blockade induces gut microbiota translocation that augments extraintestinal anti-tumor immunity

Choi, Y. et al. (BioRxiv) doi: 10.1101/2022.01.26.477865

STING controls T cell memory fitness during infection through Tcell intrinsic and IDO dependent mechanisms

Quaney, M.J. et al. (BioRxiv) doi: 10.1101/2022.03.19.484992

Longitudinal single cell transcriptional and epigenetic mapping of effector, memory, and exhausted CD8 T cells reveals shared biological circuits across distinct cell fates

Giles, J.R. et al. (BioRxiv) doi: 10.1101/2022.03.27.485974

In Utero Activation of NK Cells in Congenital CMV Infection 

Vabeen, A.V. et al. (BioRxiv) doi: 10.1101/2022.04.04.487059

The CD58:CD2 axis is co-regulated with PD-L1 via CMTM6 and governs anti-tumor immunity. 

Ho, P. et al. (BioRxiv) doi: 10.1101/2022.03.21.485049

Selected Nature Reviews Immunology Highlight

Nuclear envelope disruption triggers hallmarks of aging in lung alveolar macrophages

De Silva, N.S. et al. (BioRxiv) doi: 10.1101/2022.02.17.480837

Microbial Energy Metabolism Fuels a CSF2-dependent Intestinal Macrophage Niche within Tertiary Lymphoid Organs

Chiaranunt, P. et al. (BioRxiv) doi: 10.1101/2022.03.23.485563

2022 - March

Three functionally distinct classes of cGAS proteins in nature revealed by self-DNA-induced interferon responses

Mosallanejad, K. et al. (BioRxiv) doi: 10.1101/2022.03.09.483681

Selected Nature Reviews Immunology Highlight

Germinal center block exacerbates extrafollicular responses and accelerates autoimmune disease progression in a murine lupus model

Voss, L.F. et al. (BioRxiv) doi: 10.1101/2022.03.04.482991

Pancreas resident macrophage-induced fibrosis has divergent roles in pancreas inflammatory injury and PDAC

Baer, J.M. et al. (BioRxiv) doi: 10.1101/2022.02.09.479745

Selected Nature Reviews Immunology Highlight

2022 - February

Divergent clonal differentiation trajectories of T cell exhaustion

Daniel, B. et al. (BioRxiv) doi: 10.1101/2021.12.16.472900

Selected Nature Reviews Immunology Highlight

Microenvironmental Sensing by Fibroblasts Controls Macrophage Population Size

Zhou, X., Franklin, R. et al. (BioRxiv) doi: 10.1101/2022.01.18.476683

2022 - January

Structurally and functionally distinct early antibody responses predict COVID-19 disease trajectory and mRNA vaccine response

Chakraborty, S. et al. (BioRxiv) doi: 10.1101/2021.05.25.445649

The hyper-transmissible SARS-CoV-2 Omicron variant exhibits significant antigenic change, vaccine escape and a switch in cell entry mechanisms

Willett, B.J. et al. (medRxiv) doi: 10.1101/2022.01.03.21268111

Selected Nature Reviews Immunology Highlight

Overactive STAT3 drives accumulation of disease-associated CD21low B cells

Masle-Farquhar, E. et al. (BioRxiv) doi: 10.1101/2021.12.20.473595

IFN-γ-independent control of M. tuberculosis requires CD4 T cell-derived GM-CSF and activation of HIF-1α

Van Dis, E. et al. (BioRxiv) doi: 10.1101/2021.12.16.473015

Differentiation of a CD4+/CD8ab+ Double Positive T cell Population From the CD8 Pool is Sufficient To mediate Graft-vs-Host Disease but not Graft-vs-Leukemia Effects

Hess, N.J. et al. (BioRxiv) doi: 10.1101/2022.01.11.475845

2021 - December

Antigen presentation by type 3 innate lymphoid cells instructs the differentiation of gut microbiota-specific regulatory T cells

Kedmi, R. et al. (BioRxiv) doi: 10.1101/2021.11.19.469318

Selected Nature Reviews Immunology Highlight

γδ T cells are effectors of immune checkpoint blockade in mismatch repair-deficient colon cancers with antigen presentation defects

de Vries, N.L. et al. (BioRxiv) doi: 10.1101/2021.01.14.464229

Inhibition of microbial deconjugation of micellar bile acids protects against intestinal permeability and liver injury

Li, D.K. et al. (BioRxiv) doi: 10.1101/2021.03.24.436896

Tertiary lymphoid structures induced by CXCL13-producing CD4+ T cells increase tumor infiltrating CD8+ T cells and B cells in ovarian cancer

Ukita, M. et al. (BioRxiv) doi: 10.1101/2021.12.01.470493

Selected Nature Reviews Immunology Highlight

2021 - November

Microbiome-specific T follicular helper cells drive tertiary lumphoid structures and anti-tumor immunity against colorectal cancer

Overacre-Delgoffe, A.E. et al. (BioRxiv) doi: 10.1101/2021.01.27.428417

Commensal bacteria promote type I interferon signalling to maintain immune tolerance 

Vasques Ayala, A. et al. (BioRxiv) doi: 10.1101/2021.10.21.464743

Pan-cancer mapping of single T cell profiles reveals a TCF1:CXCR6-CXCL16 regulatory axis essential for effective anti-tumor immunity

Jerby-Arnon, L. et al. (BioRxiv) doi: 10.1101/2021.10.31.466532

Selected Nature Reviews Immunology Highlight

2021 - October

Hematopoietic stem and progenitor cells integrate Bacteroides-derived innate immune signals to promote gut tissue repair

Hayashi, Y. et al. (BioRxiv) doi: 10.1101/2021.10.05.463122

Spatiotemporal co-dependency between macrophages and exhausted CD8+ T cells in cancer

Kersten, K. et al. (BioRxiv) doi: 10.1101/2021.09.27.461866

Selected Nature Reviews Immunology Highlight

Predictive framework of macrophage activation 

Sanin, D.E. et al. (BioRxiv) doi: 10.1101/2021.08.02.454825

Selected Nature Reviews Immunology Highlight

2021 - September

Induction of transposable element expression is central to innate sensing

Rookhuizen DC et al. (BioRxiv) doi:10.1101/2021.09.10.457789

Selected Nature Reviews Immunology Highlight

SARS-CoV-2 mRNA vaccination elicits robust and persistent T follicular helper cell response in humans

Mudd PA et al. (BioRxiv) doi:10.1101/2021.09.08.459485

Excess dietary sugar impairs colonic epithelial regeneration 1 in response to damage

Burr et al. (BioRxiv) doi: 10.1101/2021.08.18.456840

2021 - June

Signatures of mast cell activation are associated with severe COVID-19

Tan J. et al. (MedRxiv) DOI: 10.1101/2021.05.31.21255594

The extracellular ATP receptor P2RX7 imprints a pro-memory transcriptional signature in effector CD8+ T cells

Vardam-Kaur, T. et al. (BioRxiv) DOI: 10.1101/2021.05.25.445679

Selected Nature Reviews Immunology Highlight

2021 - May

Active Surveillance Characterizes Human Intratumoral T Cell Exhaustion

You, R. et al. (BioRxiv) DOI: 10.1101/2021.05.06.443033

Selected Nature Reviews Immunology Highlight

The transcription factor EGR2 is indispensable for tissue-specific imprinting of alveolar macrophages in health and tissue repair

McCowan, J. et al. (BioRxiv) DOI: 10.1101/2021.05.06.442095

Differentiation of exhausted CD8 T cells after termination of chronic antigen stimulation stops short of achieving functional T cell memory

Tonnerre, P. et al. (BioRxiv) DOI: 10.1101/2021.04.03.437705

Selected Nature Reviews Immunology Highlight

Hematopoietic stem cell requirement for macrophage regeneration is tissue-specific

Eddins, D.J. et al. (BioRxiv) DOI: 10.1101/2021.04.08.439077

2021 - April

When killers become thieves: trogocytosed PD-1 inhibits NK cells in cancer

Hasim, M.S. et al. (BioRxiv) DOI: 10.1101/2020.06.26.174342

Selected Nature Reviews Immunology Highlight

Alveolar macrophages strictly rely on GM-CSF from alveolar epithelial type 2 cells before and after birth

Gschwend, J. et al. (BioRxiv) DOI: 10.1101/2021.04.01.438051

Selected Nature Reviews Immunology Highlight

Extracellular Delivery of Functional Mitochondria Reverses the Dysfunction of CD4+ T Cells in Aging

Headley, C.A. et al. (BioRxiv) DOI: 10.1101/2021.02.21.432151

2021 - March

Negligible impact of SARS-CoV-2 variants on CD4+ and CD8+ T cell reactivity in COVID-19 exposed donors and vaccinees

Tarke, A. et al. (BioRxiv) DOI: 10.1101/2021.02.27.433180
Selected Nature Reviews Immunology Highlight

The skin environment controls local dendritic cell differentiation and function through innate IL-13

Mayer, J.U. et al. (BioRxiv) DOI: 10.1101/2021.01.05.425466

Selected Nature Reviews Immunology Highlight

Murine ex vivo cultured alveolar macrophages provide a novel tool to study tissue-resident macrophage behavior and function

Gorki, A.D. et al. (BioRxiv) DOI: 10.1101/2021.02.11.430791

Sting orchestrates the crosstalk between polyunsaturated fatty acids metabolism and inflammatory responses

Vila, I.K. et al. (BioRxiv) DOI: 10.1101/2020.12.22.423950

CINS: Cell Interaction Network inference from Single cell expression data

Yuan, Y. et al. (BioRxiv) DOI: 10.1101/2021.02.22.432206

2021 - February

Maternal infection promotes offspring tissue-specific immune fitness

Lim, A.I. et al (BioRxiv). DOI: 10.1101/2021.01.13.426542

Selected Nature Reviews Immunology Highlight

Novel gut pathobionts confound results in a widely used model of human inflammatory disease

Forster, S.C. et al. (BioRxiv) DOI: 10.1101/2021.02.09.430393

MTHFD2 is a Metabolic Checkpoint Controlling Effector and Regulatory T Cell Fate and Function

Sugiura, A. et al. (BioRxiv) DOI: 10.1101/2021.02.03.428939

Selected Nature Reviews Immunology Highlight

Combining an alarmin HMGN1 peptide with PD-L1 blockade facilitates stem-like CD8+ T cell expansion and results in robust anti-tumor effects

Chen, C.Y. et al. (BioRxiv) DOI: 10.1101/2020.12.15.422990

A reservoir of stem-like CD8 T cells in the tumor-draining lymph node maintains the ongoing anti-tumor immune response

Connolly, KA. et al. (BioRxiv) DOI: 10.1101/2021.01.27.428467

Altered basal lipid metabolism underlies the functional impairment of naive CD8+ T cells in elderly humans

Nicoli, F. et al. (BioRxiv) DOI: 10.1101/2020.09.24.311704

2021 - January

Multi-antigen recognition circuits overcome challenges of specificity, heterogeneity, and durability in T cell therapy for glioblastoma

Choe, JH. et al. (BioRxiv) DOI: 10.1101/2021.01.07.425632

Selected Nature Reviews Immunology Highlight

Diverse Functional Autoantibodies in Patients with COVID-19

Wang, E.Y. et al. (MedRxiv) DOI: 10.1101/2020.12.10.20247205

Selected Nature Reviews Immunology Highlight

Neoantigen driven B cell and CD4+ T follicular helper cell collaboration promotes robust anti-tumor CD8+ T cell responses

Cui, C. et al. (BioRxiv) DOI: 10.1101/2020.12.23.424168

2020 - December

A monoclonal antibody against staphylococcal enterotoxin B superantigen inhibits SARS-CoV-2 entry in vitro

Cheng, M.H. et al. (BioRxiv) DOI: 10.1101/2020.11.24.395079
Selected Nature Reviews Immunology Highlight

ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activation

De Reuver et al. (BioRxiv) DOI: 10.1101/2020.12.04.411702

Selected Nature Reviews Immunology Highlight

Vaccination reshapes the virus-specific T cell repertoire in unexposed adults

Pan*, Y.G., Aiamkitsumrit, B. et al. (BioRxiv) DOI: 10.1101/2020.10.01.322958

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