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Latest Preprint Reviews

Human inborn errors of long-chain fatty acid oxidation show impaired inflammatory responses to TLR4-ligand LPS

Mosegaard S. et al. (BioRxiv) DOI: 10.1101/2023.08.30.555512

Homeostatic, repertoire and transcriptional relationships between colon T regulatory cell subsets.

Ramanan D. et al. (BioRxiv) DOI: 10.1101/2023.05.17.541199

Memory Th1 cells modulate heterologous diseases through innate function.

Rakebrandt*,  Yassini* et al. (BioRxiv) DOI: 10.1101/2023.03.22.533799

T:B cell communication in ectopic lymphoid follicles in CNS autoimmunity

Kolz A. et al. (bioRxiv) DOI:10.1101/2023.06.01.543004

Pannexin-1 channels promote CD8+ T cell effector and memory responses through distinct intracellular pathways

Trupti Vardam-Kaur et al. (BioRxiv)  DOI: 10.1101/2023.04.19.537580

Group 2 innate lymphoid cells constrain type 3/17 lymphocytes in shared stromal niches to restrict liver fibrosis

Sbierski-Kind*, Cautivo* et al. (Biorxiv) DOI: 10.1101/2023.04.26.537913

Universal recording of cell-cell contacts in vivo for interaction-based transcriptomics

Nakandakari-Higa et al. (BioRxiv) DOI: 10.1101/2023.03.16.533003

Glioblastoma induces the recruitment and differentiation of hybrid neutrophils from skull bone marrow

Lad BM et al. (BioRxiv) DOI:10.1101/2023.03.24.534105

Perforin-2 is a pore-forming effector of endocytic escape in cross-presenting dendritic cells

Rodríguez-Silvestre et al. (BioRxiv) DOI: 10.1101/2023.01.31.525875

Antigen-presenting type-I conventional dendritic cells facilitate curative checkpoint blockade immunotherapy in pancreatic cancer

Mahadevan K.K. et al. (BioRxiv) DOI: 10.1101/2023.03.05.531191

Unstable EBV latency drives inflammation in multiple sclerosis patient derived spontaneous B cells

Soldan S. et al. (Research Square) DOI: 10.21203/

Tregs constrain CD8+ T cell priming required for curative intratumorally anchored anti-4-1BB immunotherapy

Palmeri J.R. et al. (BioRxiv) DOI:10.1101/2023.01.30.526116

A Novel MHC-Independent Mechanism of Tumor Cell Killing by CD8+ T Cells

Lerner*, Woroniecka* et al. (BioRxiv). DOI: 10.1101/2023.02.02.526713


A Distinct Phenotype of Polarized Memory B Cell holds IgE Memory

Koenig, J. et al. (BioRxiv) DOI: 10.1101/2023.01.25.525495 

Sexual dimorphism in obesity is governed by RELMα regulation of adipose macrophages and eosinophils

Li, J. et al. (BioRxiv) DOI: 10.1101/2023.01.13.523880

A conserved family of immune effectors cleaves cellular ATP upon viral infection

Rousset, F et al. (BioRxiv) DOI: 10.1101/2023.01.24.525353

Synthetic STING agonists elicit powerful vaccine adjuvancy providing robust central memory and anti-tumor effects

Towner et al. (BioRxiv) DOI: 10.1101/2023.01.04.522614

The maternal microbiome regulates infant respiratory disease susceptibility via intestinal Flt3L expression and plasmacyoid dendritic cell haematopoiesis

Sikder M.A.A. et al. (BioRxiv) DOI: 10.1101/2023.01.05.522516

Human T follicular helper clones seed the germinal center-resident regulatory pool

Le Coz C. et al. (BioRxiv) DOI: 10.1101/2022.10.26.513910

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Immunogenicity of non-canonical HLA-I tumor ligands identified through proteogenomics

Lozano-Rabella, M. et al. (BioRxiv) DOI: 10.1101/2022.11.07.514886

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Human intestinal epithelial cells can internalize luminal fungi via LC3-associated phagocytosis

Cohen-Kedar, S. et al. (BioRxiv) DOI: 10.1101/2022.12.14.520372

B cell depletion attenuates CD27 signaling of T helper cells in multiple sclerosis

Ulutekin, C. et al. (MedRxiv) DOI: 10.1101/2022.10.17.22281079

Cystatin F (Cst7) drives sex-dependent changes in microglia in an amyloid-driven model of Alzheimer’s Disease

Daniels M.J.D. et al. (BioRxiv) DOI: 10.1101/2022.11.18.516922

Enhanced STAT5a activation rewires exhausted CD8 T cells during chronic stimulation to acquire a hybrid durable effector like state

Beltra J.-C. et al. (BioRxiv) DOI: 10.1101/2022.10.03.509766

Eradication of tumors with pre-existing antigenic heterogeneity by vaccine-mediated co-engagement of CAR T and endogenous T-cells

Ma Y. et al. (BioRxiv) DOI: 10.1101/2022.10.05.511036

Single-cell transcriptomics of resected human traumatic brain injury tissues reveals acute activation of endogenous retroviruses in oligodendrocytes

Garza R. et al. (BioRxiv) DOI: 10.1101/2022.09.07.506982

Release of the pre-assembled naRNA-LL37 composite DAMP re-defines neutrophil extracellular traps (NETs) as intentional DAMP webs

Bork F. et al. (BioRxiv) DOI: 10.1101/2022.07.26.499571

Long-term retention of antigens in germinal centres is controlled by the spatial organisation of the follicular dendritic cell network

Martinez-Riano A. et al. (BioRxiv) DOI: 10.1101/2022.09.06.506650

GATA4 regionalizes intestinal metabolism and barrier function to prevent immunopathology

Earley Z. et al. (BioRxiv) DOI: 10.1101/2021.10.28.466194

Terminal differentiation and persistence of effector regulatory T cells essential for the prevention of intestinal inflammation

Dikiy S. et al. (BioRxiv) DOI: 10.1101/2022.05.16.492030

A unique epigenomic landscape defines CD8+ tissue-resident memory T cells

Buquicchio F. et al. (BioRxiv) DOI: 10.1101/2022.05.04.490680

Unaltered T cell responses to common antigens in individuals with Parkinson’s disease

Williams G.P. et al. (BioRxiv) DOI: 10.1101/2022.04.05.487195

Distinct gene expression by expanded clones of quiescent memory CD4+ T cells harboring intact latent HIV-1 proviruses

Weymar G.H.J. et al. (BioRxiv) DOI: 10.1101/2022.03.02.482683

In Utero Activation of NK Cells in Congenital CMV Infection

Vabeen A.V. et al. (BioRxiv) DOI: 10.1101/2022.04.04.487059

Induction of a CD8 T cell intrinsic DNA damage and repair response isassociated with clinical response to PD-1 blockade in uterine canc

Muroyama Y. et al. (BioRxiv) DOI: 10.1101/2022.04.16.488552

Sex differences in NK cells mediated by the X-linked epigenetic regulator UTX

Cheng M. et al. (BioRxiv) DOI: 10.1101/2022.04.21.489076

Integrated protein and transcriptome high-throughput spatial profiling

Ben-Chetrit N. et al. (BioRxiv) DOI: 10.1101/2022.03.15.484516

Brain resident memory T cells rapidly expand and initiate neuroinflammatory responses following CNS injury and viral infection

Ayasoufi K. et al. (BioRxiv) DOI: 10.1101/2022.04.08.487707

STING controls T cell memory fitness during infection through Tcell intrinsic and IDO dependent mechanisms

Quaney M.J. et al. (BioRxiv) DOI: 10.1101/2022.03.19.484992

The CD58:CD2 axis is co-regulated with PD-L1 via CMTM6 and governs anti-tumor immunity.

Ho P. et al. (BioRxiv) DOI: 10.1101/2022.03.21.485049

Longitudinal single cell transcriptional and epigenetic mapping of effector, memory, and exhausted CD8 T cells reveals shared biological circuits across distinct cell fates

Giles J.R. et al. (BioRxiv) DOI: 10.1101/2022.03.27.485974

Nuclear envelope disruption triggers hallmarks of aging in lung alveolar macrophages

De Silva N.S. et al. (BioRxiv) DOI: 10.1101/2022.02.17.480837

Immune checkpoint blockade induces gut microbiota translocation that augments extraintestinal anti-tumor immunity

Choi Y. et al. (BioRxiv) DOI: 10.1101/2022.01.26.477865

Microbial Energy Metabolism Fuels a CSF2-dependent Intestinal Macrophage Niche within Tertiary Lymphoid Organs

Chiaranunt P. et al. (BioRxiv) DOI: 10.1101/2022.03.23.485563

Germinal center block exacerbates extrafollicular responses and accelerates autoimmune disease progression in a murine lupus model

Voss L.F. et al. (BioRxiv) DOI: 10.1101/2022.03.04.482991

Three functionally distinct classes of cGAS proteins in nature revealed by self-DNA-induced interferon responses

Mosallanejad K. et al. (BioRxiv) DOI: 10.1101/2022.03.09.483681

Pancreas resident macrophage-induced fibrosis has divergent roles in pancreas inflammatory injury and PDAC

Baer J.M. et al. (BioRxiv) DOI: 10.1101/2022.02.09.479745

Microenvironmental Sensing by Fibroblasts Controls Macrophage Population Size

Zhou X., Franklin R. et al. (BioRxiv) DOI: 10.1101/2022.01.18.476683

Divergent clonal differentiation trajectories of T cell exhaustion

Daniel B. et al. (BioRxiv) DOI: 10.1101/2021.12.16.472900

The hyper-transmissible SARS-CoV-2 Omicron variant exhibits significant antigenic change, vaccine escape and a switch in cell entry mechanisms

Willett B.J. et al. (MedRxiv) DOI: 10.1101/2022.01.03.21268111

IFN-γ-independent control of M. tuberculosis requires CD4 T cell-derived GM-CSF and activation of HIF-1α

Van Dis E. et al. (BioRxiv) DOI: 10.1101/2021.12.16.473015

Overactive STAT3 drives accumulation of disease-associated CD21low B cells

Masle-Farquhar E. et al. (BioRxiv) DOI: 10.1101/2021.12.20.473595

Differentiation of a CD4+/CD8ab+ Double Positive T cell Population From the CD8 Pool is Sufficient To mediate Graft-vs-Host Disease but not Graft-vs-Leukemia Effects

Hess et al. (BioRxiv) DOI: 10.1101/2022.01.11.475845

Structurally and functionally distinct early antibody responses predict COVID-19 disease trajectory and mRNA vaccine response

Chakraborty S. et al. (BioRxiv) DOI: 10.1101/2021.05.25.445649

Tertiary lymphoid structures induced by CXCL13-producing CD4+ T cells increase tumor infiltrating CD8+ T cells and B cells in ovarian cancer

Ukita M. et al. (BioRxiv) DOI: 10.1101/2021.12.01.470493

Inhibition of microbial deconjugation of micellar bile acids protects against intestinal permeability and liver injury

Li D.K. et al. (BioRxiv) DOI: 10.1101/2021.03.24.436896

Antigen presentation by type 3 innate lymphoid cells instructs the differentiation of gut microbiota-specific regulatory T cells

Kedmi R. et al. (BioRxiv) DOI: 10.1101/2021.11.19.469318

γδ T cells are effectors of immune checkpoint blockade in mismatch repair-deficient colon cancers with antigen presentation defects

de Vries N.L. et al. (BioRxiv) DOI: 10.1101/2021.10.14.464229

Commensal bacteria promote type I interferon signalling to maintain immune tolerance

Vasques Ayala A. et al. (BioRxiv) DOI: 10.1101/2021.10.21.464743

Microbiome-specific T follicular helper cells drive tertiary lymphoid structures and anti-tumor immunity against colorectal cancer

Overacre-Delgoffe A.E. et al. (BioRxiv) DOI: 10.1101/2021.10.31.466532

Pan-cancer mapping of single T cell profiles reveals a TCF1:CXCR6-CXCL16 regulatory axis essential for effective anti-tumor immunity

Jerby-Arnon L. et al. (BioRxiv) doi: 10.1101/2021.10.31.466532

Predictive framework of macrophage activation

Sanin D.E. et al. (BioRxiv) DOI: 10.1101/2021.08.02.454825

Spatiotemporal co-dependency between macrophages and exhausted CD8+ T cells in cancer

Kersten K. et al. (BioRxiv) DOI: 10.1101/2021.09.27.461866

Hematopoietic stem and progenitor cells integrate Bacteroides-derived innate immune signals to promote gut tissue repair

Hayashi Y. et al. (BioRxiv) DOI: 10.1101/2021.10.05.463122

Induction of transposable element expression is central to innate sensing

Rookhuizen D.C. et al. (BioRxiv) DOI: 10.1101/2021.09.10.457789

SARS-CoV-2 mRNA vaccination elicits robust and persistent T follicular helper cell response in humans

Mudd P.A. et al. (BioRxiv) DOI: 10.1101/2021.09.08.459485

Excess dietary sugar impairs colonic epithelial regeneration 1 in response to damage

Burr A.H.P. et al. (BioRxiv) DOI: 10.1101/2021.08.18.456840

The extracellular ATP receptor P2RX7 imprints a pro-memory transcriptional signature in effector CD8+ T cells

Vardam-Kaur T. et al. (BioRxiv) DOI: 10.1101/2021.05.25.445679

Signatures of mast cell activation are associated with severe COVID-19

Tan J., Anderson D.E. et al. (MedRxiv) DOI: 10.1101/2021.05.31.21255594v1

Active Surveillance Characterizes Human Intratumoral T Cell Exhaustion

You R. et al. (BioRxiv) DOI: 10.1101/2021.05.06.443033

Differentiation of exhausted CD8 T cells after termination of chronic antigen stimulation stops short of achieving functional T cell memory

Tonnerre P et al. (BioRxiv) DOI: 10.1101/2021.04.03.437705

The transcription factor EGR2 is indispensable for tissue-specific imprinting of alveolar macrophages in health and tissue repair

McCowan J. et al. (BioRxiv) DOI: 10.1101/2021.05.06.442095

Hematopoietic stem cell requirement for macrophage regeneration is tissue-specific

Eddins D.J. et al. (BioRxiv) DOI: 10.1101/2021.04.08.439077

Extracellular Delivery of Functional Mitochondria Reverses the Dysfunction of CD4+ T Cells in Aging

Headley C.A. et al. (BioRxiv) DOI: 10.1101/2021.02.21.432151

When killers become thieves: trogocytosed PD-1 inhibits NK cells in cancer

Hasim M.S. et al. (BioRxiv) DOI: 10.1101/2020.06.26.174342

Alveolar macrophages strictly rely on GM-CSF from alveolar epithelial type 2 cells before and after birth

Gschwend J. et al. (BioRxiv) DOI: 10.1101/2021.04.01.438051

CINS: Cell Interaction Network inference from Single cell expression data

Yuan Y. et al. (BioRxiv) DOI: 10.1101/2021.02.22.432206

Sting orchestrates the crosstalk between polyunsaturated fatty acids metabolism and inflammatory responses

Vila I.K. et al. (BioRxiv) DOI: 10.1101/2020.12.22.423950

Negligible impact of SARS-CoV-2 variants on CD4+ and CD8+ T cell reactivity in COVID-19 exposed donors and vaccinees

Tarke A. et al. (BioRxiv) DOI: 10.1101/2021.02.27.433180

The skin environment controls local dendritic cell differentiation and function through innate IL-13

Mayer J.U. et al. (BioRxiv) DOI: 10.1101/2021.01.05.425466

Murine ex vivo cultured alveolar macrophages provide a novel tool to study tissue-resident macrophage behavior and function

Gorki A.-D. et al. (BioRxiv) DOI: 10.1101/2021.02.11.430791

MTHFD2 is a Metabolic Checkpoint Controlling Effector and Regulatory T Cell Fate and Function

Sugiura A. et al. (BioRxiv) DOI: 10.1101/2021.02.03.428939

Altered basal lipid metabolism underlies the functional impairment of naive CD8+ T cells in elderly humans

Nicoli F. et al. (BioRxiv) DOI: 10.1101/2020.09.24.311704

Maternal infection promotes offspring tissue-specific immune fitness

Lim A.I. et al. (BioRxiv) DOI: 10.1101/2021.01.13.426542

Novel gut pathobionts confound results in a widely used model of human inflammatory disease

Forster S.C. et al. (BioRxiv) DOI: 10.1101/2021.02.09.430393

A reservoir of stem-like CD8 T cells in the tumor-draining lymph node maintains the ongoing anti-tumor immune response

Connolly K.A. et al. (BioRxiv) DOI: 10.1101/2021.01.27.428467

Combining an alarmin HMGN1 peptide with PD-L1 blockade facilitates stem-like CD8+ T cell expansion and results in robust anti-tumor effects

Chen C.-Y. et al. (BioRxiv) DOI: 10.1101/2020.12.15.422990

Diverse Functional Autoantibodies in Patients with COVID-19

Wang E.Y. et al. (MedRxiv) DOI: 10.1101/2020.12.10.20247205

Skin-resident immune cells actively coordinate their distribution with epidermal cells during homeostasis

Park S. et al. (MedRxiv) DOI: 10.1101/2021.01.08.425932

ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activation

De Reuver et al. (BioRxiv) DOI: 10.1101/2020.12.04.411702

Neoantigen driven B cell and CD4+ T follicular helper cell collaboration promotes robust anti-tumor CD8+ T cell responses

Cui C. et al. (BioRxiv) DOI: 10.1101/2020.12.23.424168

Multi-antigen recognition circuits overcome challenges of specificity, heterogeneity, and durability in T cell therapy for glioblastoma

Choe J.H. et al. (BioRxiv) DOI: 10.1101/2021.01.07.425632

A monoclonal antibody against staphylococcal enterotoxin B superantigen inhibits SARS-CoV-2 entry in vitro

Cheng, M.H. et al. (BioRxiv) DOI: 10.1101/2020.11.24.395079

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Vaccination reshapes the virus-specific T cell repertoire in unexposed adults

Pan*, Aiamkitsumrit* et al. (BioRxiv) DOI: 10.1101/2020.10.01.322958

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