Preprint Club
A cross-institutional Journal Club Initiative
Latest Preprint Reviews
Immunopeptidomics informs discovery and delivery of Mycobacterium tuberculosis MHC-II antigens for vaccine design
Leddy et al. (BioRxiv) DOI: 10.1101/2024.10.02.616386
PD-1 controls differentiation, survival, and TCR affinity evolution of stem-like CD8+ T cells
Hor et al. (BioRxiv) DOI: 10.1101/2024.08.02.606241
Synaptic synergy of T cell receptor and interleukin 2 receptor in CD8+ T cells
Capera et al. (BioRxiv) DOI: 10.1101/2024.08.13.607831
Androgen Signaling Restricts Glutaminolysis to Drive Sex-Specific Th17 Metabolism
Chowdhury et al. (BioRxiv) DOI: 10.1101/2023.02.10.527741
B cell-mediated antigen presentation promotes adverse cardiac remodeling in chronic heart failure
Lovell et al. (BioRxiv) DOI:10.1101/2024.05.08.593153
Inhibition of NFAT promotes loss of tissue resident uterine natural killer cells and attendant pregnancy complications in humans
Asiimwe et al. (BioRxiv) DOI: 10.1101/2024.03.07.583906
Epigenetic signature and key transcriptional regulators of human antigen-specific type 1 regulatory T cells
Alma-Martina Cepika, et al. (BioRxiv) DOI: 10.1101/2024.03.07.582969
Low Avidity T cells drive endogenous tumor immunity in mice and humans
Singhaviranon et al. (Research Square) DOI: 10.21203/rs.3.rs-3903457/v1
Granzyme B-based CAR T cells block metastasis by eliminating circulating tumor cells
Bin Sun, et.al. (BioRxiv) DOI: 10.1101/2024.03.18.585442
Interleukin-1 receptor antagonist is a conserved driver of tuberculosis
Kotov. et al. (BioRxiv) DOI: 10.1101/2023.10.27.564420
CD39 is expressed on functional effector and tissue resident memory CD8+ T cells
Isaacs, JF et al. (BioRxiv) DOI: 10.1101/2024.03.15.585252v1
Microbiota encoded fatty-acid metabolism expands tuft cells to protect tissues homeostasis during Clostridioides difficile infection in the large intestine
Kellogg et al. (BioRxiv) DOI: 10.1101/2024.01.29.574039
Host-derived oxidized phospholipids initiate effector-triggered immunity fostering lethality upon microbial encounter.
Di Gioia et al. (BioRxiv) DOI: 10.1101/2023.11.21.568047
Cytotoxic CD4+ T cells in the bone marrow compromise healthy ageing by enhancing granulopoiesis
Enrique Gabamdé-Rodrigez, Gonzalo Soto-Heredero, et al. (BioRxiv) DOI: 10.1101/2024.01.26.577360
IQGAP2 regulates blood-brain barrier immune dynamics
Katdare KA et al. (BioRxiv) DOI: 10.1101/2023.02.07.527394
Cancer immunotherapy responses persist after lymph node resection
Zhou H et al. (BioRxiv) DOI: 10.1101/2023.09.19.558262
Lymphatic vessel transit seeds precursors to cytotoxic resident memory T cells in skin draining lymph nodes
Heim, et al. (BioRxiv) DOI: 10.1101/2023.08.29.555369
Convergent evolution of monocyte differentiation in adult skin instructs Langerhans cell identity
Appios A, Daview J, Sirvent S, et al. (BioRxiv) DOI: 10.1101/2023.11.13.566862
Interpretable inflammation landscape of circulating immune cells
Jimenez-Gracia et al. (BioRxiv) DOI: 10.1101/2023.11.28.568839
Monocyte-derived microglia with Dnmt3a mutation cause motor pathology in aging mice
Kim et al. (BioRxiv) DOI:10.1101/2023.11.16.567402
A Specialized Epithelial Cell Type Regulating Mucosal Immunity and Driving Human Crohn’s Disease
Li et al. (BioRxiv) DOI: 10.1101/2023.09.30.560293
Single cell analysis uncovers striking cellular heterogeneity of lung infiltrating Tregs during eosinophilic vs. neutrophilic allergic airway inflammation
Iamsawat et al. (BioRxiv) DOI: 10.1101/2023.09.23.559152
Iron is critical for mucosal-associated invariant T cell metabolism and effector functions.
Eimear R. et al. (Research Square) DOI: 10.21203/rs.3.rs-3358434/v1
A spatial human thymus cell atlas mapped to a continuous tissue axis
Yayon*, Kedlian*, Boehme* et al. (BioRxiv) DOI: 10.1101/2023.10.25.562925
Immune landscape of tertiary lymphoid structures in hepatocellular carcinoma (HCC) treated with neoadjuvant immune checkpoint blockade
Shu D.H. et al. (BioRxiv) DOI: 10.1101/2023.10.16.562104
Multimodal profiling of peripheral blood identifies proliferating circulating effector CD4+ T cells as predictors for response to integrin α4β7-blocking therapy in patients with inflammatory bowel disease
Horn V. et al. (BioRxiv) DOI: 10.1101/2023.10.01.560386
Maternal IL-10 restricts fetal emergency myelopoiesis
Collins A. et al. (BioRxiv) DOI: 10.1101/2023.09.13.557548
Murine classical monocyte subsets display distinct functions and fates
Trzebanski et al. (BioRxiv) DOI: 10.1101/2023.07.29.551083
Commensal myeloid crosstalk in neonatal skin regulates long-term cutaneous type 17 inflammation
Dhariwala M.O. et al. (BioRxiv) DOI:10.1101/2023.09.29.560039
TAPIR: a T-cell receptor language model for predicting rare and novel targets.
Fast et al. (BioRxiv) DOI: 10.1101/2023.09.12.557285
Bacterial Sphingolipids Exacerbate Colitis by Inhibiting ILC3-derived IL-22 Production
Bao, B. et al. (BioRxiv) DOI: 10.1101/2023.09.05.555400
HIF-1α-mediated mitochondrial-glycolytic reprogramming controls the transition of precursor to terminally exhausted T cells
Wu et al. (BioRxiv) DOI: 10.1101/2023.08.31.555662
Temporal profiling of human lymphoid tissues reveals coordinated defence to viral challenge
Coates M.L. et al. (BioRxiv) DOI: 10.1101/2023.09.15.558006
Homeostatic, repertoire and transcriptional relationships between colon T regulatory cell subsets.
Ramanan D. et al. (BioRxiv) DOI: 10.1101/2023.05.17.541199
Memory Th1 cells modulate heterologous diseases through innate function.
Rakebrandt*, Yassini* et al. (BioRxiv) DOI: 10.1101/2023.03.22.533799
T:B cell communication in ectopic lymphoid follicles in CNS autoimmunity
Kolz A. et al. (bioRxiv) DOI:10.1101/2023.06.01.543004
Perforin-2 is a pore-forming effector of endocytic escape in cross-presenting dendritic cells
Rodríguez-Silvestre et al. (BioRxiv) DOI: 10.1101/2023.01.31.525875
Antigen-presenting type-I conventional dendritic cells facilitate curative checkpoint blockade immunotherapy in pancreatic cancer
Mahadevan K.K. et al. (BioRxiv) DOI: 10.1101/2023.03.05.531191
Unstable EBV latency drives inflammation in multiple sclerosis patient derived spontaneous B cells
Soldan S. et al. (Research Square) DOI: 10.21203/rs.3.rs-2398872/v1
Tregs constrain CD8+ T cell priming required for curative intratumorally anchored anti-4-1BB immunotherapy
Palmeri J.R. et al. (BioRxiv) DOI:10.1101/2023.01.30.526116
A Novel MHC-Independent Mechanism of Tumor Cell Killing by CD8+ T Cells
Lerner*, Woroniecka* et al. (BioRxiv). DOI: 10.1101/2023.02.02.526713
A Distinct Phenotype of Polarized Memory B Cell holds IgE Memory
Koenig, J. et al. (BioRxiv) DOI: 10.1101/2023.01.25.525495
Sexual dimorphism in obesity is governed by RELMα regulation of adipose macrophages and eosinophils
Li, J. et al. (BioRxiv) DOI: 10.1101/2023.01.13.523880
A conserved family of immune effectors cleaves cellular ATP upon viral infection
Rousset, F et al. (BioRxiv) DOI: 10.1101/2023.01.24.525353
Synthetic STING agonists elicit powerful vaccine adjuvancy providing robust central memory and anti-tumor effects
Towner et al. (BioRxiv) DOI: 10.1101/2023.01.04.522614
The maternal microbiome regulates infant respiratory disease susceptibility via intestinal Flt3L expression and plasmacyoid dendritic cell haematopoiesis
Sikder M.A.A. et al. (BioRxiv) DOI: 10.1101/2023.01.05.522516
Human T follicular helper clones seed the germinal center-resident regulatory pool
Le Coz C. et al. (BioRxiv) DOI: 10.1101/2022.10.26.513910
Immunogenicity of non-canonical HLA-I tumor ligands identified through proteogenomics
Lozano-Rabella, M. et al. (BioRxiv) DOI: 10.1101/2022.11.07.514886
Human intestinal epithelial cells can internalize luminal fungi via LC3-associated phagocytosis
Cohen-Kedar, S. et al. (BioRxiv) DOI: 10.1101/2022.12.14.520372
B cell depletion attenuates CD27 signaling of T helper cells in multiple sclerosis
Ulutekin, C. et al. (MedRxiv) DOI: 10.1101/2022.10.17.22281079
Cystatin F (Cst7) drives sex-dependent changes in microglia in an amyloid-driven model of Alzheimer’s Disease
Daniels M.J.D. et al. (BioRxiv) DOI: 10.1101/2022.11.18.516922
Enhanced STAT5a activation rewires exhausted CD8 T cells during chronic stimulation to acquire a hybrid durable effector like state
Beltra J.-C. et al. (BioRxiv) DOI: 10.1101/2022.10.03.509766
Eradication of tumors with pre-existing antigenic heterogeneity by vaccine-mediated co-engagement of CAR T and endogenous T-cells
Ma Y. et al. (BioRxiv) DOI: 10.1101/2022.10.05.511036
Single-cell transcriptomics of resected human traumatic brain injury tissues reveals acute activation of endogenous retroviruses in oligodendrocytes
Garza R. et al. (BioRxiv) DOI: 10.1101/2022.09.07.506982
Release of the pre-assembled naRNA-LL37 composite DAMP re-defines neutrophil extracellular traps (NETs) as intentional DAMP webs
Bork F. et al. (BioRxiv) DOI: 10.1101/2022.07.26.499571
Long-term retention of antigens in germinal centres is controlled by the spatial organisation of the follicular dendritic cell network
Martinez-Riano A. et al. (BioRxiv) DOI: 10.1101/2022.09.06.506650
GATA4 regionalizes intestinal metabolism and barrier function to prevent immunopathology
Earley Z. et al. (BioRxiv) DOI: 10.1101/2021.10.28.466194
Terminal differentiation and persistence of effector regulatory T cells essential for the prevention of intestinal inflammation
Dikiy S. et al. (BioRxiv) DOI: 10.1101/2022.05.16.492030
A unique epigenomic landscape defines CD8+ tissue-resident memory T cells
Buquicchio F. et al. (BioRxiv) DOI: 10.1101/2022.05.04.490680
Unaltered T cell responses to common antigens in individuals with Parkinson’s disease
Williams G.P. et al. (BioRxiv) DOI: 10.1101/2022.04.05.487195
Distinct gene expression by expanded clones of quiescent memory CD4+ T cells harboring intact latent HIV-1 proviruses
Weymar G.H.J. et al. (BioRxiv) DOI: 10.1101/2022.03.02.482683
In Utero Activation of NK Cells in Congenital CMV Infection
Vabeen A.V. et al. (BioRxiv) DOI: 10.1101/2022.04.04.487059
Induction of a CD8 T cell intrinsic DNA damage and repair response isassociated with clinical response to PD-1 blockade in uterine canc
Muroyama Y. et al. (BioRxiv) DOI: 10.1101/2022.04.16.488552
Sex differences in NK cells mediated by the X-linked epigenetic regulator UTX
Cheng M. et al. (BioRxiv) DOI: 10.1101/2022.04.21.489076
Integrated protein and transcriptome high-throughput spatial profiling
Ben-Chetrit N. et al. (BioRxiv) DOI: 10.1101/2022.03.15.484516
Brain resident memory T cells rapidly expand and initiate neuroinflammatory responses following CNS injury and viral infection
Ayasoufi K. et al. (BioRxiv) DOI: 10.1101/2022.04.08.487707
STING controls T cell memory fitness during infection through Tcell intrinsic and IDO dependent mechanisms
Quaney M.J. et al. (BioRxiv) DOI: 10.1101/2022.03.19.484992
The CD58:CD2 axis is co-regulated with PD-L1 via CMTM6 and governs anti-tumor immunity.
Ho P. et al. (BioRxiv) DOI: 10.1101/2022.03.21.485049
Longitudinal single cell transcriptional and epigenetic mapping of effector, memory, and exhausted CD8 T cells reveals shared biological circuits across distinct cell fates
Giles J.R. et al. (BioRxiv) DOI: 10.1101/2022.03.27.485974
Nuclear envelope disruption triggers hallmarks of aging in lung alveolar macrophages
De Silva N.S. et al. (BioRxiv) DOI: 10.1101/2022.02.17.480837
Immune checkpoint blockade induces gut microbiota translocation that augments extraintestinal anti-tumor immunity
Choi Y. et al. (BioRxiv) DOI: 10.1101/2022.01.26.477865
Microbial Energy Metabolism Fuels a CSF2-dependent Intestinal Macrophage Niche within Tertiary Lymphoid Organs
Chiaranunt P. et al. (BioRxiv) DOI: 10.1101/2022.03.23.485563
Germinal center block exacerbates extrafollicular responses and accelerates autoimmune disease progression in a murine lupus model
Voss L.F. et al. (BioRxiv) DOI: 10.1101/2022.03.04.482991
Three functionally distinct classes of cGAS proteins in nature revealed by self-DNA-induced interferon responses
Mosallanejad K. et al. (BioRxiv) DOI: 10.1101/2022.03.09.483681
Pancreas resident macrophage-induced fibrosis has divergent roles in pancreas inflammatory injury and PDAC
Baer J.M. et al. (BioRxiv) DOI: 10.1101/2022.02.09.479745
Microenvironmental Sensing by Fibroblasts Controls Macrophage Population Size
Zhou X., Franklin R. et al. (BioRxiv) DOI: 10.1101/2022.01.18.476683
Divergent clonal differentiation trajectories of T cell exhaustion
Daniel B. et al. (BioRxiv) DOI: 10.1101/2021.12.16.472900