
Preprint Club
A cross-institutional Journal Club Initiative
Latest Preprint Reviews

Control of Inflammatory Response by Tissue Microenvironment
Wu et al. (BioRxiv)

The immunometabolic topography of tuberculosis granulomas governs cellular organization and bacterial control
McCaffrey, E.F. & Delmastro, A.C. et al. (BioRxiv) DOI: 10.1101/2025.02.18.638923

Likely circulation of a coronavirus in roe deer
populations suggested by SARS-CoV-2 serological investigation in France
Perez et al 2025. (BioRxiv) DOI: 10.1101/2025.02.19.639030

Microbial metabolism of food allergens determines the severity of IgE-mediated anaphylaxis
Sánchez-Martínez et al. (BioRxiv) DOI: 2025.02.17.638013v1

A microenvironment-driven, HLA-II-associated insulin neoantigen elicits persistent memory T cell activation in diabetes
Srivastava et al. (BioRxiv)

Neoantigens drive adoptively transferred CD8 T cells to long-lived effectors mediated by lymph node trafficking

Poxvirus attack of anti-viral defense pathways unleashes an effector-triggered NF-κB response
BC Remick et al., (bioRxiv) DOI: 10.1101/2025.03.04.641538

Monocyte control of organismal energy homeostasis
Martins*, Blankehaus* et al. (BioRxiv) DOI: 10.1101/2025.02.20.639373

Androgen Signaling in Type 2 Innate Lymphoid Cells Drives Sex Differences in Helicobacter-Induced Gastric Inflammation and Atrophy
Duncan et al. (BioRxiv) DOI:10.1101/2025.03.14.643321

CDKN2ALow cancer cells outcompete macrophages for microenvironmental zinc to drive immunotherapy resistance.
Buj et al. (BioRxiv) DOI: 10.1101/2025.02.08.637227

Type 1 interferons induced upon respiratory viral infection impair lung metastatic initiation
Farais et al. (BioRxiv) DOI: 10.1101/2024.12.23.630113

Tumor-associated macrophages enhance tumor innervation and spinal cord repair
Dolci et al. (BioRxiv) DOI: 10.1101/2024.12.19.629374

BLOC1S1 control of vacuolar organelle fidelity modulates TH2 cell immunity and allergy susceptibility
Sharma et al. (BioRxiv) DOI: 10.1101/2024.03.21.586144

Macrophages orchestrate elimination of Shigella from the intestinal epithelial cell niche via TLR-induced IL-12 and IFN-γ
Eislmayr et al. (BioRxiv) DOI:10.1101/2025.01.20.633976

Discovery of a Potent and Selective Inhibitor of Human NLRP3 with a Novel Binding Modality and Mechanism of Action
Wilhelmsen et al. (BioRxiv) DIO: 10.1101/2024.12.21.629867

IL-10 Targets IRFs to Suppress IFN and Inflammatory Response Genes by Epigenetic Mechanisms
Bikash Mishra et al. (BioRxiv) DOI: 10.1101/2024.11.07.622491

Lymph Node Fibroblast Phenotypes and Immune Crosstalk Regulated by Podoplanin Activity
Makris et al. (BioRxiv) DOI: 10.1101/2022.12.01.518753

Dietary Restriction Enhances CD8⁺ T Cell Ketolysis to Limit Exhaustion and Boost Anti-Tumor Immunity
Oswald B.M. et al. (BioRxiv) DOI: 10.1101/2024.11.14.621733

Early life RSV infection as a preventable risk factor for asthma
De Leeuw et al., Research Square , DOI: 10.21203/rs.3.rs-5366915

Peptide-MHC-targeted retroviruses enable in vivo expansion and gene delivery to tumor-specific T cells
Xu et al. (BioRxiv). DOI: 10.1101/2024.09.18.613594

Immunopeptidomics informs discovery and delivery of Mycobacterium tuberculosis MHC-II antigens for vaccine design
Leddy et al. (BioRxiv) DOI: 10.1101/2024.10.02.616386

PD-1 controls differentiation, survival, and TCR affinity evolution of stem-like CD8+ T cells
Hor et al. (BioRxiv) DOI: 10.1101/2024.08.02.606241

Synaptic synergy of T cell receptor and interleukin 2 receptor in CD8+ T cells
Capera et al. (BioRxiv) DOI: 10.1101/2024.08.13.607831

Androgen Signaling Restricts Glutaminolysis to Drive Sex-Specific Th17 Metabolism
Chowdhury et al. (BioRxiv) DOI: 10.1101/2023.02.10.527741

B cell-mediated antigen presentation promotes adverse cardiac remodeling in chronic heart failure
Lovell et al. (BioRxiv) DOI:10.1101/2024.05.08.593153

Inhibition of NFAT promotes loss of tissue resident uterine natural killer cells and attendant pregnancy complications in humans
Asiimwe et al. (BioRxiv) DOI: 10.1101/2024.03.07.583906

Epigenetic signature and key transcriptional regulators of human antigen-specific type 1 regulatory T cells
Alma-Martina Cepika, et al. (BioRxiv) DOI: 10.1101/2024.03.07.582969

Low Avidity T cells drive endogenous tumor immunity in mice and humans
Singhaviranon et al. (Research Square) DOI: 10.21203/rs.3.rs-3903457/v1

Granzyme B-based CAR T cells block metastasis by eliminating circulating tumor cells
Bin Sun, et.al. (BioRxiv) DOI: 10.1101/2024.03.18.585442

Interleukin-1 receptor antagonist is a conserved driver of tuberculosis
Kotov. et al. (BioRxiv) DOI: 10.1101/2023.10.27.564420

CD39 is expressed on functional effector and tissue resident memory CD8+ T cells
Isaacs, JF et al. (BioRxiv) DOI: 10.1101/2024.03.15.585252v1

Microbiota encoded fatty-acid metabolism expands tuft cells to protect tissues homeostasis during Clostridioides difficile infection in the large intestine
Kellogg et al. (BioRxiv) DOI: 10.1101/2024.01.29.574039

Host-derived oxidized phospholipids initiate effector-triggered immunity fostering lethality upon microbial encounter.
Di Gioia et al. (BioRxiv) DOI: 10.1101/2023.11.21.568047

Cytotoxic CD4+ T cells in the bone marrow compromise healthy ageing by enhancing granulopoiesis
Enrique Gabamdé-Rodrigez, Gonzalo Soto-Heredero, et al. (BioRxiv) DOI: 10.1101/2024.01.26.577360

IQGAP2 regulates blood-brain barrier immune dynamics
Katdare KA et al. (BioRxiv) DOI: 10.1101/2023.02.07.527394

Cancer immunotherapy responses persist after lymph node resection
Zhou H et al. (BioRxiv) DOI: 10.1101/2023.09.19.558262

Lymphatic vessel transit seeds precursors to cytotoxic resident memory T cells in skin draining lymph nodes
Heim, et al. (BioRxiv) DOI: 10.1101/2023.08.29.555369

Convergent evolution of monocyte differentiation in adult skin instructs Langerhans cell identity
Appios A, Daview J, Sirvent S, et al. (BioRxiv) DOI: 10.1101/2023.11.13.566862

Interpretable inflammation landscape of circulating immune cells
Jimenez-Gracia et al. (BioRxiv) DOI: 10.1101/2023.11.28.568839

Monocyte-derived microglia with Dnmt3a mutation cause motor pathology in aging mice
Kim et al. (BioRxiv) DOI:10.1101/2023.11.16.567402

A Specialized Epithelial Cell Type Regulating Mucosal Immunity and Driving Human Crohn’s Disease
Li et al. (BioRxiv) DOI: 10.1101/2023.09.30.560293

Single cell analysis uncovers striking cellular heterogeneity of lung infiltrating Tregs during eosinophilic vs. neutrophilic allergic airway inflammation
Iamsawat et al. (BioRxiv) DOI: 10.1101/2023.09.23.559152

Iron is critical for mucosal-associated invariant T cell metabolism and effector functions.
Eimear R. et al. (Research Square) DOI: 10.21203/rs.3.rs-3358434/v1

A spatial human thymus cell atlas mapped to a continuous tissue axis
Yayon*, Kedlian*, Boehme* et al. (BioRxiv) DOI: 10.1101/2023.10.25.562925

Immune landscape of tertiary lymphoid structures in hepatocellular carcinoma (HCC) treated with neoadjuvant immune checkpoint blockade
Shu D.H. et al. (BioRxiv) DOI: 10.1101/2023.10.16.562104

Multimodal profiling of peripheral blood identifies proliferating circulating effector CD4+ T cells as predictors for response to integrin α4β7-blocking therapy in patients with inflammatory bowel disease
Horn V. et al. (BioRxiv) DOI: 10.1101/2023.10.01.560386

Maternal IL-10 restricts fetal emergency myelopoiesis
Collins A. et al. (BioRxiv) DOI: 10.1101/2023.09.13.557548

Murine classical monocyte subsets display distinct functions and fates
Trzebanski et al. (BioRxiv) DOI: 10.1101/2023.07.29.551083

Commensal myeloid crosstalk in neonatal skin regulates long-term cutaneous type 17 inflammation
Dhariwala M.O. et al. (BioRxiv) DOI:10.1101/2023.09.29.560039

TAPIR: a T-cell receptor language model for predicting rare and novel targets.
Fast et al. (BioRxiv) DOI: 10.1101/2023.09.12.557285

Bacterial Sphingolipids Exacerbate Colitis by Inhibiting ILC3-derived IL-22 Production
Bao, B. et al. (BioRxiv) DOI: 10.1101/2023.09.05.555400

HIF-1α-mediated mitochondrial-glycolytic reprogramming controls the transition of precursor to terminally exhausted T cells
Wu et al. (BioRxiv) DOI: 10.1101/2023.08.31.555662

Temporal profiling of human lymphoid tissues reveals coordinated defence to viral challenge
Coates M.L. et al. (BioRxiv) DOI: 10.1101/2023.09.15.558006

Homeostatic, repertoire and transcriptional relationships between colon T regulatory cell subsets.
Ramanan D. et al. (BioRxiv) DOI: 10.1101/2023.05.17.541199

Memory Th1 cells modulate heterologous diseases through innate function.
Rakebrandt*, Yassini* et al. (BioRxiv) DOI: 10.1101/2023.03.22.533799

T:B cell communication in ectopic lymphoid follicles in CNS autoimmunity
Kolz A. et al. (bioRxiv) DOI:10.1101/2023.06.01.543004

Perforin-2 is a pore-forming effector of endocytic escape in cross-presenting dendritic cells
Rodríguez-Silvestre et al. (BioRxiv) DOI: 10.1101/2023.01.31.525875

Antigen-presenting type-I conventional dendritic cells facilitate curative checkpoint blockade immunotherapy in pancreatic cancer
Mahadevan K.K. et al. (BioRxiv) DOI: 10.1101/2023.03.05.531191

Unstable EBV latency drives inflammation in multiple sclerosis patient derived spontaneous B cells
Soldan S. et al. (Research Square) DOI: 10.21203/rs.3.rs-2398872/v1

Tregs constrain CD8+ T cell priming required for curative intratumorally anchored anti-4-1BB immunotherapy
Palmeri J.R. et al. (BioRxiv) DOI:10.1101/2023.01.30.526116

A Novel MHC-Independent Mechanism of Tumor Cell Killing by CD8+ T Cells
Lerner*, Woroniecka* et al. (BioRxiv). DOI: 10.1101/2023.02.02.526713

A Distinct Phenotype of Polarized Memory B Cell holds IgE Memory
Koenig, J. et al. (BioRxiv) DOI: 10.1101/2023.01.25.525495

Sexual dimorphism in obesity is governed by RELMα regulation of adipose macrophages and eosinophils
Li, J. et al. (BioRxiv) DOI: 10.1101/2023.01.13.523880

A conserved family of immune effectors cleaves cellular ATP upon viral infection
Rousset, F et al. (BioRxiv) DOI: 10.1101/2023.01.24.525353

Synthetic STING agonists elicit powerful vaccine adjuvancy providing robust central memory and anti-tumor effects
Towner et al. (BioRxiv) DOI: 10.1101/2023.01.04.522614