Latest Preprints
27 okt. 2025
Serpine1 plays a critical role in Th17 cell differentiation and psoriasis pathogenesis
K. Saimaier et al. (BioRxiv) DOI: 2025.05.08.652800
27 okt. 2025
RORγt+ APCs require a distinct cis-regulatory element to instruct tolerance to dietary antigens
Zhao et al. (ResearchSquare) DOI: 10.21203/rs.3.rs-4865841/v1
25 okt. 2025
Brain-Engrafted Monocyte-derived Macrophages from Blood and Skull-Bone Marrow Exhibit Distinct Identities from Microglia
Du et al. (BioRxiv) DOI: 10.1101/2024.08.08.606900
23 okt. 2025
Single cell proteomic analysis defines discrete neutrophil functional states in human glioblastoma
Sadiku & Brenes et al. (BioRxiv)
8 okt. 2025
STAT3 operates as an inflammation-dependent transcriptional switch
Simon Grassmann, et al. BioRxiv
14 juli 2025
Mapping the nanoscale organization of the human cell surface proteome reveals new functional associations and surface antigen clusters
Floyd et al. (BioRxiv)
29 juni 2025
Microbial metabolism of food allergens determines the severity of IgE-mediated anaphylaxis
Sánchez-Martínez et al. (BioRxiv)
DOI: 2025.02.17.638013v1
27 juni 2025
Likely circulation of a coronavirus in roe deer populations suggested by SARS-CoV-2 serological investigation in France
Perez et al. (BioRxiv)
26 juni 2025
The immunometabolic topography of tuberculosis granulomas governs cellular organization and bacterial control
McCaffrey, E.F. & Delmastro, A.C. et al. (BioRxiv)
20 juni 2025
Control of Inflammatory Response by Tissue Microenvironment
Wu et al. (BioRxiv)
11 juni 2025
Submicron-Sampling of Living Cells by Macrophages
Fan et al. (BioRxiv)
22 maj 2025
A microenvironment-driven, HLA-II-associated insulin neoantigen elicits persistent memory T cell activation in diabetes
Srivastava et al. (BioRxiv)
20 maj 2025
Niche Macrophages Recycle Iron to Tumor Cells and Foster Erythroblast Mimicry to Promote Bone Metastasis and Anemia
Han et al. (BioRxiv)
18 maj 2025
IL-25-induced memory ILC2s mediate long-term small intestinal adaptation
Cortez et al. (BioRxiv)
16 maj 2025
A pan-cancer atlas of T cell targets
Li, G. et al (BioRxiv)
26 apr. 2025
Neoantigens drive adoptively transferred CD8 T cells to long-lived effectors mediated by lymph node trafficking
Wittling et al. (BioRxiv)
22 apr. 2025
Maternal immune activation imprints a regulatory T cell deficiency in offspring that drives an autism-like phenotype
Ellul et al. (BioRixv)
18 apr. 2025
The phagosome-mediated anti-bacterial immunity is governed by the proton-activated chloride channel in peritoneal macrophages
Cheng et al. (BioRxiv)
11 apr. 2025
Functional memory T cells are derived from exhausted clones and expanded by checkpoint blockade
Raposo, C.J. et al. (BioRxiv)
8 apr. 2025
Poxvirus attack of anti-viral defense pathways unleashes an effector-triggered NF-κB response
BC Remick et al. (BioRxiv)
6 apr. 2025
Androgen Signaling in Type 2 Innate Lymphoid Cells Drives Sex Differences in Helicobacter-Induced Gastric Inflammation and Atroph
Duncan et al. (BioRxiv)
5 apr. 2025
Monocyte control of organismal energy homeostasis
Martins*, Blankehaus* et al. (BioRxiv)
27 mars 2025
CDKN2ALow cancer cells outcompete macrophages for microenvironmental zinc to drive immunotherapy resistance.
Buj et al. (BioRxiv)
17 mars 2025
Tumor-associated macrophages enhance tumor innervation and spinal cord repair
Dolci et al. (BioRxiv)
14 mars 2025
Chronic Viral Reactivation and Associated Host Immune Response and Clinical Outcomes in Acute COVID-19 and Post-Acute Sequelae of COVID-19
Maguire et al. (BioRxiv)
12 mars 2025
Lymph nodes link sex-biased immune aging to compromised antigen recognition
Menzel et al. (BioRxiv)
10 mars 2025
Type 1 interferons induced upon respiratory viral infection impair lung metastatic initiation
Farais et al. (BioRxiv)
27 feb. 2025
Tumor-associated macrophages enhance tumor innervation and spinal cord repair
Dolci et al. (BioRxiv)
20 feb. 2025
Resident Tissue Macrophages Govern Intraocular Pressure Homeostasis
Liu et al. (BioRxiv)
10 feb. 2025
Type 1 lymphocytes and interferon-γ accumulate in the thalamus and restrict seizure susceptibility after traumatic brain injury
Mroz et al. (BioRixv)
8 feb. 2025
BLOC1S1 control of vacuolar organelle fidelity modulates TH2 cell immunity and allergy susceptibility
Sharma et al. (BioRxiv)
31 jan. 2025
Memory-Phenotype Ly49+ CD8 T emerging from the thymus develop into two subsets with distinct immune functions
Laubreton et al. (BioRxiv)
30 jan. 2025
Macrophages orchestrate elimination of Shigella from the intestinal epithelial cell niche via TLR-induced IL-12 and IFN-γ
Eislmayr et al. (BioRxiv)
20 jan. 2025
Discovery of a Potent and Selective Inhibitor of Human NLRP3 with a Novel Binding Modality and Mechanism of Action
Wilhelmsen et al. (BioRxiv)
17 jan. 2025
IL-10 Targets IRFs to Suppress IFN and Inflammatory Response Genes by Epigenetic Mechanisms
Bikash Mishra et al. (BioRxiv)
15 jan. 2025
Lymph Node Fibroblast Phenotypes and Immune Crosstalk Regulated by Podoplanin Activity
Makris et al. (BioRxiv)
20 dec. 2024
Dietary Restriction Enhances CD8⁺ T Cell Ketolysis to Limit Exhaustion and Boost Anti-Tumor Immunity
Oswald B.M. et al. (BioRxiv)
17 dec. 2024
Early life RSV infection as a preventable risk factor for asthma
De Leeuw et al. (Research Square)
15 dec. 2024
Interferon Epsilon Protects Epithelial Barriers from Viral Infection through Autocrine
Casazza et al. (BioRxiv)
12 dec. 2024
Peptide-MHC-targeted retroviruses enable in vivo expansion and gene delivery to tumor-specific T cells
Xu et al. (BioRxiv)
1 nov. 2024
Immunopeptidomics informs discovery and delivery of Mycobacterium tuberculosis MHC-II antigens for vaccine design
Leddy et al. (BioRxiv)
23 okt. 2024
Multi-Omics Atlas-Assisted Discovery of Transcription Factors for Selective T Cell State Programming
Kay-Chung et al. (BioRxiv)
15 okt. 2024
A lymphoid tissue chemokine checkpoint prevents loss of CD8+ T cell functionality
Altenburger, LM. et al. (BioRxiv)
13 okt. 2024
Microbiota-induced plastic T cells enhance immune control of antigen-sharing tumors
Najar et al. (BioRxiv)
10 okt. 2024
Monocyte-derived cells but not Microglia cause Oxidative Tissue Damage in Neuroinflammation
Villar-Vesga et al. (BioRxiv)
2 okt. 2024
PD-1 controls differentiation, survival, and TCR affinity evolution of stem-like CD8+ T cells
Hor et al. (BioRxiv)
1 okt. 2024
Synaptic synergy of T cell receptor and interleukin 2 receptor in CD8+ T cells
Capera et al. (BioRxiv)
1 juli 2024
Androgen Signaling Restricts Glutaminolysis to Drive Sex-Specific Th17 Metabolism
Chowdhury et al. (BioRxiv)
8 maj 2024
Tuft cell IL-17RB restrains IL-25 bioavailability and reveals context-dependent ILC2 hypo proliferation
Feng X et al. (BioRxiv)
7 maj 2024
Microbiota-derived inosine programs protective CD8+ T cell responses against influenza in newborns
Stevens et al. (BioRxiv)
6 maj 2024
Plasmacytoid dendritic cells are dispensable or detrimental in murine systemic or resiratory viral infections
Ngo C. et al. (BioRxiv)
5 maj 2024
B cell-mediated antigen presentation promotes adverse cardiac remodeling in chronic heart failure
Lovell et al. (BioRxiv)
3 maj 2024
Inhibition of NFAT promotes loss of tissue resident uterine natural killer cells and attendant pregnancy complications in humans
Asiimwe et al. (BioRxiv)
2 maj 2024
Epigenetic signature and key transcriptional regulators of human antigen-specific type 1 regulatory T cells
Alma-Martina Cepika, et al. (BioRxiv)
1 maj 2024
Arp2/3 complex-dependent actin regulation protects the survival of tissue-resident mast cells.
Kaltenbach et al. (BioRxiv)
4 apr. 2024
Low Avidity T cells drive endogenous tumor immunity in mice and humans
Singhaviranon et al. (Research Square)
3 apr. 2024
Breast Cancer Macrophage Heterogeneity and Self-renewal are Determined by Spatial Localization
Ben-Chetrit et al. (BioRxiv)
2 apr. 2024
CD4+ TRM sustain the chronic phase of auto-immune neuroinflammatory disease
Pignata et al. (BioRxiv)
1 apr. 2024
Granzyme B-based CAR T cells block metastasis by eliminating circulating tumor cells
Bin Sun, et.al. (BioRxiv)
20 mars 2024
CAR-engineered lymphocyte persistence is governed by a FAS ligand/FAS auto-regulatory circuit
Yi et al. (BioRxiv)
2 mars 2024
Interleukin-1 receptor antagonist is a conserved driver of tuberculosis
Kotov. et al. (BioRxiv)
1 mars 2024
Opposing effects of pre-existing antibody and memory T cell help on the dynamics of recall germinal centers
Schiepers A. et al. (BioRxiv)
1 mars 2024
CD39 is expressed on functional effector and tissue resident memory CD8+ T cells
Isaacs, JF et al. (BioRxiv)
4 feb. 2024
Microbiota encoded fatty-acid metabolism expands tuft cells to protect tissues homeostasis during Clostridioides difficile infection in the large intestine
Kellogg et al. (BioRxiv)
3 feb. 2024
Host-derived oxidized phospholipids initiate effector-triggered immunity fostering lethality upon microbial encounter.
2 feb. 2024
Cytotoxic CD4+ T cells in the bone marrow compromise healthy ageing by enhancing granulopoiesis
Enrique Gabamdé-Rodrigez, Gonzalo Soto-Heredero, et al. (BioRxiv)
1 feb. 2024
IQGAP2 regulates blood-brain barrier immune dynamics
Katdare KA et al. (BioRxiv)
17 jan. 2024
Tuft cell derived acetylcholine is an effector of type 2 immunity and directly targets helminth parasites in the gut lumen.
Ndjim M. et al. (BioRxiv)
3 jan. 2024
Cancer immunotherapy responses persist after lymph node resection
Zhou H et al. (BioRxiv)
2 jan. 2024
Lymphatic vessel transit seeds precursors to cytotoxic resident memory T cells in skin draining lymph nodes
Heim, et al. (BioRxiv)
1 jan. 2024
Convergent evolution of monocyte differentiation in adult skin instructs Langerhans cell identity
Appios A, Daview J, Sirvent S, et al. (BioRxiv)
3 dec. 2023
Interpretable inflammation landscape of circulating immune cells
Jimenez-Gracia et al. (BioRxiv)
2 dec. 2023
Monocyte-derived microglia with Dnmt3a mutation cause motor pathology in aging mice
Kim et al. (BioRxiv)
1 dec. 2023
A Specialized Epithelial Cell Type Regulating Mucosal Immunity and Driving Human Crohn’s Disease
Li et al. (BioRxiv)
7 nov. 2023
Single cell analysis uncovers striking cellular heterogeneity of lung infiltrating Tregs during eosinophilic vs. neutrophilic allergic airway inflammation
Iamsawat et al. (BioRxiv)
6 nov. 2023
CD163 and Tim-4 identify resident intestinal macrophages across sub-tissular regions that are spatially regulated by TGF-β
Prise I.E. et al. (BioRxiv)
5 nov. 2023
Tumor-wide RNA splicing aberrations generate immunogenic public neoantigens
Kwok D.W. et al. (BioRxiv)
4 nov. 2023
An “alert state” ribosome population acts as a master regulator of cytokine-mediated processes
Dopler et al. (BioRxiv)
3 nov. 2023
Iron is critical for mucosal-associated invariant T cell metabolism and effector functions.
Eimear R. et al. (Research Square)
2 nov. 2023
A spatial human thymus cell atlas mapped to a continuous tissue axis
Yayon*, Kedlian*, Boehme* et al. (BioRxiv)
1 nov. 2023
Immune landscape of tertiary lymphoid structures in hepatocellular carcinoma (HCC) treated with neoadjuvant immune checkpoint blockade
Shu D.H. et al. (BioRxiv)
7 okt. 2023
Multimodal profiling of peripheral blood identifies proliferating circulating effector CD4+ T cells as predictors for response to integrin α4β7-blocking therapy in patients with inflammatory bowel disease
Horn V. et al. (BioRxiv)
6 okt. 2023
Maternal IL-10 restricts fetal emergency myelopoiesis
Collins A. et al. (BioRxiv)
5 okt. 2023
Murine classical monocyte subsets display distinct functions and fates
Trzebanski et al. (BioRxiv)
4 okt. 2023
Commensal myeloid crosstalk in neonatal skin regulates long-term cutaneous type 17 inflammation
Dhariwala M.O. et al. (BioRxiv)
3 okt. 2023
Adipocytes regulate fibroblast function, and their loss contributes to fibroblast dysfunction in inflammatory diseases
Faust H. et al. (bioRxiv)
2 okt. 2023
TAPIR: a T-cell receptor language model for predicting rare and novel targets.
1 okt. 2023
Bacterial Sphingolipids Exacerbate Colitis by Inhibiting ILC3-derived IL-22 Production
Bao, B. et al. (BioRxiv)
4 sep. 2023
HIF-1α-mediated mitochondrial-glycolytic reprogramming controls the transition of precursor to terminally exhausted T cells
Wu et al. (BioRxiv)
3 sep. 2023
Human inborn errors of long-chain fatty acid oxidation show impaired inflammatory responses to TLR4-ligand LPS
Mosegaard S. et al. (BioRxiv)
2 sep. 2023
Temporal profiling of human lymphoid tissues reveals coordinated defence to viral challenge
Coates M.L. et al. (BioRxiv)
1 sep. 2023
The tissue-resident regulatory T cell pool is shaped by transient multi-tissue migration and a conserved residency program
Burton O*, Bricard O* et al. (BioRxiv)
3 juni 2023
Homeostatic, repertoire and transcriptional relationships between colon T regulatory cell subsets.
Ramanan D. et al. (BioRxiv)
2 juni 2023
Memory Th1 cells modulate heterologous diseases through innate function.
Rakebrandt*, Yassini* et al. (BioRxiv)
1 juni 2023
T:B cell communication in ectopic lymphoid follicles in CNS autoimmunity
Kolz A. et al. (BioRxiv)
3 maj 2023
Pannexin-1 channels promote CD8+ T cell effector and memory responses through distinct intracellular pathways
Trupti Vardam-Kaur et al. (BioRxiv)
2 maj 2023
Group 2 innate lymphoid cells constrain type 3/17 lymphocytes in shared stromal niches to restrict liver fibrosis
Sbierski-Kind*, Cautivo* et al. (Biorxiv)
1 maj 2023
Universal recording of cell-cell contacts in vivo for interaction-based transcriptomics
Nakandakari-Higa et al. (BioRxiv)
2 apr. 2023
Glioblastoma induces the recruitment and differentiation of hybrid neutrophils from skull bone marrow
Lad BM et al. (BioRxiv)